Focusing immune responses by immunogen hyperglycosylation
We engineer immunogens in silico to add glycans onto the surfaces we don't want antibodies to see — masking immunodominant but variable regions so the response focuses on the conserved, protective epitopes we choose. Our HyperImmunISE (Hyperglycosylating Immunogen through In Silico Engineering) workflow places glycosylation sites that maximize surface coverage while minimizing steric overlap, iterating against structural evaluation before experimental validation.
Glycan masking — hiding the distractions
Adding N-linked glycans to immunodominant, non-conserved surfaces dampens off-target responses and redirects B cells toward the conserved epitopes that confer broad protection.
In silico design — HyperImmunISE
An algorithm selects glycosylation sites that maximize surface coverage while minimizing steric clashes, iterating with structural evaluation to produce immunogen candidates for experimental validation.