Our core technology
BCR-Seq & Ig-Seq
Two complementary technologies that, together, reveal both the sequences and the abundances of the antibodies that protect us — connecting the B cells that encode antibodies with the antibody proteins actually circulating in serum.
BCR-Seq — the antibody-encoding repertoire
Next-generation sequencing of antibody (BCR) transcripts from B cells, with native VH:VL heavy/light chain pairing, captures the full sequence diversity of the antibody repertoire.
Ig-Seq — the circulating antibody proteome
Affinity purification followed by high-resolution proteomic mass spectrometry quantifies the antibodies actually secreted into serum, revealing which clones dominate the protective response.